Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.46 |
| ▸ | MTOR | P42345 | 3/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 12/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 12/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 12/20 | 0.45 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1857827 | 0.89 | PIK3CA (0.42) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1856716 | 0.88 | PIK3CA (0.48) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1864401 | 0.83 | PIK3CA (0.47) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL4440222 | 0.80 | PIK3CA (0.46) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1862201 | 0.79 | PIK3CA (0.67) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL189671 | 0.78 | PIK3CA (0.54) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL10316564 | 0.77 | PIK3CA (0.57) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1859279 | 0.77 | PIK3CA (0.53) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL3616815 | 0.77 | PIK3CD (0.72) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL4438133 | 0.77 | PIK3CA (0.54) | PIK3CAMTORPIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046799-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Genentech, Inc. (US) | 2009-04-15 | — | — | EP | disclosed |
| WO-2007127183-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GENENTECH, INC. (US) | 2007-11-08 | — | — | WO | disclosed |