Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.46 |
| ▸ | MTOR | P42345 | 5/20 | 0.46 |
| ▸ | PIK3R1 | P27986 | 8/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1181585 | 0.89 | PIK3CD (0.43) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL1181829 | 0.89 | PIK3CA (0.49) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL4555586 | 0.82 | PIK3CA (0.52) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL1284104 | 0.81 | PIK3CA (0.44) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL10316564 | 0.81 | PIK3CA (0.57) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL4067340 | 0.80 | PIK3CA (0.46) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL1089137 | 0.80 | PIK3CD (0.54) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL1863036 | 0.79 | PIK3CA (0.67) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL4441845 | 0.79 | PIK3CA (0.54) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| Hydrochloric Acid SCHEMBL189960 | 0.79 | PIK3CA (0.43) | PIK3CAMTORPIK3R1PIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114949-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | F.HOFFMANN-LA ROCHE AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008070740-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | F.HOFFMANN-LA ROCHE AG (CH) | 2008-06-12 | — | — | WO | disclosed |