Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 2/20 | 0.52 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.52 |
| ▸ | CDK1 | P06493 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | CDK7 | P50613 | 1/20 | 0.52 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.52 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.52 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.52 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.52 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.52 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.52 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.52 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.52 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.52 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.52 |
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4060314 | 0.99 | CDK2 (0.51) | CDK2DYRK3CDK1GSK3BCDK7 | |
| SCHEMBL4060961 | 0.90 | DYRK3 (0.55) | CDK2DYRK3CDK1GSK3BCDK7 | |
| Hydrochloric Acid SCHEMBL4060471 | 0.89 | DYRK3 (0.54) | CDK2DYRK3CDK1GSK3BCDK7 | |
| SCHEMBL3191993 | 0.89 | CDK2 (0.53) | CDK2DYRK3CDK1GSK3BCDK7 | |
| SCHEMBL4061528 | 0.88 | CDK2 (0.51) | CDK2DYRK3CDK1GSK3BCDK7 | |
| Hydrochloric Acid SCHEMBL4060387 | 0.88 | CDK2 (0.52) | CDK2DYRK3CDK1GSK3BCDK7 | |
| Hydrochloric Acid SCHEMBL4062688 | 0.87 | CDK2 (0.50) | CDK2DYRK3CDK1GSK3BCDK7 | |
| SCHEMBL27657011 | 0.86 | DYRK3 (0.47) | CDK2DYRK3CDK1GSK3BCDK7 | |
| SCHEMBL27657010 | 0.86 | DYRK3 (0.47) | CDK2DYRK3CDK1GSK3BCDK7 | |
| SCHEMBL4063350 | 0.85 | DYRK3 (0.50) | CDK2DYRK3CDK1GSK3BCDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1492785-B9 | 2-HYDROXY-3-HETEROARYLINDOLE DERIVATIVES AS GSK3 INHIBITORS | ASTRAZENECA AB (SE) | 2009-10-21 | — | — | EP | claimed |
| EP-1492785-B1 | 2-HYDROXY-3-HETEROARYLINDOLE DERIVATIVES AS GSK3 INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-03 | — | — | EP | claimed |