Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK3 | O43781 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | CDK7 | P50613 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.47 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.47 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.47 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.47 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.47 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.47 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | MLNR | O43193 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27620109 | 0.90 | GSK3B (0.49) | DYRK3CDK1CDK2GSK3BCDK7 | |
| SCHEMBL27620104 | 0.88 | DYRK3 (0.45) | DYRK3CDK1CDK2GSK3BCDK7 | |
| SCHEMBL4067810 | 0.86 | CDK2 (0.52) | DYRK3CDK1CDK2GSK3BCDK7 | |
| Hydrochloric Acid SCHEMBL4060314 | 0.85 | CDK2 (0.51) | DYRK3CDK1CDK2GSK3BCDK7 | |
| SCHEMBL27620305 | 0.84 | DYRK3 (0.42) | DYRK3CDK1CDK2GSK3BCDK7 | |
| SCHEMBL27657011 | 0.82 | DYRK3 (0.47) | DYRK3CDK1CDK2GSK3BCDK7 | |
| SCHEMBL4060961 | 0.76 | DYRK3 (0.55) | DYRK3CDK1CDK2GSK3BCDK7 | |
| Hydrochloric Acid SCHEMBL4060471 | 0.76 | DYRK3 (0.54) | DYRK3CDK1CDK2GSK3BCDK7 | |
| Hydrochloric Acid SCHEMBL27641516 | 0.76 | GSK3B (0.38) | DYRK3CDK1CDK2GSK3BCDK7 | |
| SCHEMBL3191993 | 0.75 | CDK2 (0.53) | DYRK3CDK1CDK2GSK3BCDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100519550-C | 2-oxoindole compounds having inhibitory activity on glycogen synthase kinase 3 receptor | ASTRAZENECA AB SE (SE) | 2009-07-29 | — | — | CN | claimed |
| CN-100519550-C | 2-oxoindole compounds having inhibitory activity on glycogen synthase kinase 3 receptor | ASTRAZENECA AB SE (SE) | 2009-07-29 | — | — | CN | disclosed |
| CN-1923812-A | New compounds | ASTRAZENECA AB (SE) | 2007-03-07 | — | — | CN | disclosed |