Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 1/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5459280 | 0.82 | HTR2A (0.44) | CFDHTR2AHRH1 | |
| SCHEMBL4066380 | 0.81 | SIGMAR1 (0.40) | AOC3SLC6A3SLC6A4SLC6A2MAOA | |
| SCHEMBL4066408 | 0.81 | SLC6A2 (0.44) | CFDTAAR1AOC3SLC6A3SLC6A4 | |
| SCHEMBL389419 | 0.81 | CHRM2 (0.49) | CFDAOC3HTR2AHRH1SLC6A3 | |
| SCHEMBL14983856 | 0.80 | AOC3 (0.52) | TAAR1AOC3HTR2AHRH1SLC6A3 | |
| SCHEMBL13516766 | 0.80 | AOC3 (0.52) | TAAR1AOC3HTR2AHRH1SLC6A3 | |
| SCHEMBL2680525 | 0.80 | HTR2A (0.67) | CFDTAAR1HTR2AHRH1SLC6A3 | |
| SCHEMBL4506098 | 0.80 | HTR2A (0.67) | CFDTAAR1HTR2AHRH1SLC6A3 | |
| SCHEMBL4066280 | 0.79 | SLC6A2 (0.53) | AOC3SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL3406829 | 0.78 | SLC2A1 (0.42) | AOC3SLC6A3SLC6A4SLC6A2MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686999-B1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSINE KINASES | ASTRAZENECA AB (SE) | 2009-07-01 | — | — | EP | disclosed |