Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A3 | P43003 | 1/20 | 0.46 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.46 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.46 |
| ▸ | CCR1 | P32246 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.43 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | MC3R | P41968 | 1/20 | 0.41 |
| ▸ | ALPI | P09923 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | XIAP | P98170 | 1/20 | 0.41 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4066979 | 1.00 | SLC1A3 (0.46) | SLC1A3SLC1A2SLC1A1CCR1EPHX1 | |
| SCHEMBL4062972 | 0.92 | SLC1A3 (0.53) | SLC1A3SLC1A2SLC1A1CCR1EPHX1 | |
| SCHEMBL7434946 | 0.90 | SLC1A3 (0.57) | SLC1A3SLC1A2SLC1A1CYP1A2PPARG | |
| SCHEMBL8893214 | 0.90 | SLC1A3 (0.57) | SLC1A3SLC1A2SLC1A1CYP1A2PPARG | |
| SCHEMBL8893218 | 0.90 | SLC1A3 (0.57) | SLC1A3SLC1A2SLC1A1CYP1A2PPARG | |
| SCHEMBL7434949 | 0.90 | SLC1A3 (0.57) | SLC1A3SLC1A2SLC1A1CYP1A2PPARG | |
| SCHEMBL4064868 | 0.88 | SLC1A1 (0.50) | SLC1A3SLC1A2SLC1A1CCR1SLC15A1 | |
| SCHEMBL4063823 | 0.88 | ERAP2 (0.48) | SLC1A3SLC1A2SLC1A1CCR1EPHX1 | |
| SCHEMBL7434194 | 0.86 | SLC1A3 (0.50) | SLC1A3SLC1A2SLC1A1CYP1A2PPARG | |
| SCHEMBL7434192 | 0.86 | SLC1A3 (0.50) | SLC1A3SLC1A2SLC1A1CYP1A2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966443-B1 | HETEROARYL-HEXANOIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS SELECTIVE INHIBITORS OF MIP-1-ALPHA BINDING TO ITS CCR1 RECEPTOR | PFIZER (US) | 2009-01-28 | — | — | EP | disclosed |