Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC9A1 | P19634 | 3/20 | 0.41 |
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.40 |
| ▸ | EIF4H | Q15056 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4060771 | 0.94 | PDE4A (0.40) | SLC9A1PDE4APABPC1EIF4HMEN1 | |
| SCHEMBL4068932 | 0.90 | PDE4A (0.39) | SLC9A1PDE4APABPC1EIF4HMEN1 | |
| SCHEMBL4063790 | 0.87 | HTR3A (0.40) | PDE4AELANEKCNH2L3MBTL1 | |
| SCHEMBL4067514 | 0.87 | PDE4A (0.37) | PDE4AELANEKCNH2L3MBTL1MAPT | |
| SCHEMBL4064713 | 0.86 | HTR3A (0.40) | PDE4AELANEKCNH2L3MBTL1 | |
| SCHEMBL4060477 | 0.86 | ELANE (0.41) | PDE4AELANEKCNH2MALT1 | |
| SCHEMBL4069712 | 0.85 | KDM4E (0.46) | PDE4AMEN1KMT2AALDH1A1KCNH2 | |
| SCHEMBL4063095 | 0.85 | PDE4A (0.39) | PDE4AELANEKCNH2RORC | |
| SCHEMBL4061518 | 0.84 | PDE4A (0.41) | PDE4AELANEKCNH2RORC | |
| SCHEMBL4060222 | 0.84 | PDE4A (0.39) | PDE4AELANEKCNH2L3MBTL1RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641791-B1 | 3-(GUANIDINOCARBONYL)HETEROCYCLE DERIVATIVES, PREPARATION PROCESS AND INTERMEDIATES OF THIS PROCESS, THEIR USE AS MEDICAMENTS, AND PHARMACEUTICAL COMPOSITIONS INCLUDING THEM | SANOFI AVENTIS DEUTSCHLAND (DE) | 2009-07-29 | — | — | EP | claimed |