Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCA | P06881 | 7/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4068520 | 0.93 | CALCA (0.55) | CALCAKMT2AERCC1FEN1ERCC4 | |
| SCHEMBL4059849 | 0.88 | CALCA (0.55) | CALCAKMT2AERCC1FEN1ERCC4 | |
| SCHEMBL4243888 | 0.82 | CALCA (0.53) | CALCAKMT2AERCC1FEN1ERCC4 | |
| SCHEMBL4064942 | 0.81 | CALCA (0.56) | CALCAKMT2A | |
| SCHEMBL4059314 | 0.77 | CALCA (0.50) | CALCAKMT2AERCC1FEN1ERCC4 | |
| SCHEMBL4067919 | 0.77 | CALCA (0.80) | CALCAKMT2AERCC1FEN1ERCC4 | |
| SCHEMBL4061190 | 0.77 | CALCA (0.51) | CALCAKMT2AERCC1FEN1ERCC4 | |
| SCHEMBL6490436 | 0.76 | CALCA (0.62) | CALCAKMT2AERCC1FEN1ERCC4 | |
| SCHEMBL4064947 | 0.76 | CALCA (0.54) | CALCAKMT2A | |
| SCHEMBL4070604 | 0.76 | CALCA (0.70) | CALCAKMT2AERCC1FEN1ERCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012095388-A2 | COMPOUNDS FOR TREATMENT OF FELINE LEUKEMIA IN FELIDAE | Universität Zürich (CH) | 2012-07-19 | — | — | WO | claimed |
| EP-1326865-B1 | AZA- AND POLYAZA-NAPHTHALENYL CARBOXAMIDES USEFUL AS HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2009-05-06 | — | — | EP | disclosed |