Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 14/20 | 0.72 |
| ▸ | GRK6 | P43250 | 5/20 | 0.70 |
| ▸ | JAK2 | O60674 | 1/20 | 0.61 |
| ▸ | JAK3 | P52333 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.59 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.59 |
| ▸ | AURKA | O14965 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4065647 | 0.93 | GRK6 (0.72) | NTRK1GRK6JAK2JAK3AURKA | |
| SCHEMBL4065327 | 0.87 | NTRK1 (0.68) | NTRK1GRK6JAK2JAK3 | |
| SCHEMBL3338355 | 0.87 | NTRK1 (0.70) | NTRK1GRK6CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL29794656 | 0.87 | NTRK1 (0.70) | NTRK1GRK6CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL23217099 | 0.87 | NTRK1 (0.70) | NTRK1GRK6CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL4075068 | 0.86 | NTRK1 (0.74) | NTRK1JAK2JAK3 | |
| SCHEMBL4072982 | 0.85 | NTRK1 (0.75) | NTRK1JAK2JAK3 | |
| SCHEMBL4158208 | 0.85 | NTRK1 (0.77) | NTRK1JAK2JAK3 | |
| SCHEMBL4070045 | 0.83 | NTRK1 (0.75) | NTRK1JAK2JAK3 | |
| SCHEMBL4160442 | 0.83 | NTRK1 (0.68) | NTRK1JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686999-B1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSINE KINASES | ASTRAZENECA AB (SE) | 2009-07-01 | — | — | EP | disclosed |