Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.49 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.40 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4061387 | 0.94 | MAPK14 (0.46) | MAPK14 | |
| SCHEMBL4063899 | 0.94 | MAPK14 (0.54) | MAPK14CSNK1DCSNK1EMEN1MAPK13 | |
| SCHEMBL3997933 | 0.88 | MAPK14 (0.51) | MAPK14CSNK1DCSNK1EMAPK13MAPK12 | |
| SCHEMBL4061072 | 0.88 | MAPK14 (0.55) | MAPK14CSNK1DCSNK1EMEN1MAPK13 | |
| SCHEMBL3989359 | 0.85 | MAPK14 (0.57) | MAPK14 | |
| SCHEMBL4068114 | 0.84 | MAPK14 (0.43) | MAPK14CSNK1DCSNK1EMEN1KMT2A | |
| SCHEMBL3992075 | 0.81 | MAPK14 (0.51) | MAPK14MEN1MAPK13RIPK2GMNN | |
| SCHEMBL4067857 | 0.80 | MAPK14 (0.45) | MAPK14CSNK1DCSNK1EMEN1MAPK13 | |
| SCHEMBL3990938 | 0.80 | MAPK14 (0.47) | MAPK14CSNK1DCSNK1EMEN1MAPK13 | |
| SCHEMBL4067180 | 0.80 | MAPK14 (0.49) | MAPK14MEN1MAPK13MAPTMAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713805-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2009-06-10 | — | — | EP | disclosed |