Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | ULK1 | O75385 | 8/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL588427 | 0.84 | KMT2A (0.47) | IGF1RROCK2KMT2A | |
| SCHEMBL3852710 | 0.83 | IGF1R (0.41) | IGF1RLRRK2PRKCQROCK2KMT2A | |
| SCHEMBL4073673 | 0.81 | IGF1R (0.43) | IGF1RKMT2A | |
| SCHEMBL589661 | 0.81 | IGF1R (0.46) | IGF1R | |
| SCHEMBL11938388 | 0.81 | IGF1R (0.72) | IGF1RULK1LRRK2CDK1 | |
| SCHEMBL30010241 | 0.77 | NTRK1 (0.52) | IGF1R | |
| SCHEMBL3763586 | 0.76 | IGF1R (0.38) | IGF1RKMT2A | |
| SCHEMBL4068340 | 0.74 | — | — | |
| SCHEMBL12784225 | 0.72 | CCNA2 (0.44) | IGF1RULK1LRRK2ALK | |
| SCHEMBL27815652 | 0.71 | IGF1R (0.33) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686999-B1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSINE KINASES | ASTRAZENECA AB (SE) | 2009-07-01 | — | — | EP | disclosed |
| CN-1905884-A | Pyrazole derivatives as inhibitors of receptor tyrosyne kinases | ASTRAZENECA AB (SE) | 2007-01-31 | — | — | CN | disclosed |