Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 14/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PLK4 | O00444 | 1/20 | 0.32 |
| ▸ | PAK4 | O96013 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3852710 | 0.86 | IGF1R (0.41) | IGF1RNTRK1KMT2A | |
| SCHEMBL589661 | 0.84 | IGF1R (0.46) | IGF1RNTRK1 | |
| SCHEMBL588427 | 0.84 | KMT2A (0.47) | IGF1RNTRK1KMT2A | |
| SCHEMBL4069130 | 0.81 | IGF1R (0.45) | IGF1RKMT2A | |
| SCHEMBL17304181 | 0.80 | PLK4 (0.36) | IGF1RNTRK1KMT2APLK4PAK4 | |
| SCHEMBL11343050 | 0.80 | IGF1R (0.70) | IGF1R | |
| SCHEMBL3763586 | 0.79 | IGF1R (0.38) | IGF1RKMT2ADRD2DRD4DRD3 | |
| SCHEMBL12439767 | 0.79 | IGF1R (0.58) | IGF1R | |
| SCHEMBL15195826 | 0.79 | IGF1R (0.56) | IGF1R | |
| SCHEMBL1164462 | 0.78 | IGF1R (0.66) | IGF1RNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686999-B1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSINE KINASES | ASTRAZENECA AB (SE) | 2009-07-01 | — | — | EP | disclosed |