Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.45 |
| ▸ | PIM1 | P11309 | 5/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.42 |
| ▸ | ATR | Q13535 | 2/20 | 0.41 |
| ▸ | ATRIP | Q8WXE1 | 2/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | NMT1 | P30419 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2079289 | 0.83 | MAPK14 (0.58) | MAPK14MAPK13MAPK12MAPK11ATR | |
| SCHEMBL2080167 | 0.81 | MAPK14 (0.68) | MAPK14MAPK13MAPK12MAPK11ATR | |
| SCHEMBL2078647 | 0.81 | MAPK14 (0.70) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL2079418 | 0.80 | ATR (0.58) | MAPK14ATRATRIP | |
| SCHEMBL4069855 | 0.77 | MAPK14 (0.62) | MAPK14MAPK13MAPK12MAPK11ATR | |
| SCHEMBL4067448 | 0.77 | MAPK14 (0.74) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4252715 | 0.76 | MAPK14 (0.61) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL2079373 | 0.76 | MAPK14 (0.68) | MAPK14MAPK13MAPK12MAPK11ATR | |
| SCHEMBL2079898 | 0.76 | MAPK14 (0.61) | MAPK14MAPK13MAPK12MAPK11HTR1A | |
| SCHEMBL2078608 | 0.75 | MAPK14 (0.78) | MAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049537-A1 | 1, 7-NAPHTHYRIDINE DERIVATIVES AS P38 MAP KINASE INHIBITORS | Laboratorios Almirall, S.A. (ES) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008017461-A1 | 1, 7-NAPHTHYRIDINE DERIVATIVES AS P38 MAP KINASE INHIBITORS | LABORATORIOS ALMIRALL, S.A. (ES) | 2008-02-14 | — | — | WO | disclosed |