Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 0.62 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 6/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | ATR | Q13535 | 2/20 | 0.37 |
| ▸ | ATRIP | Q8WXE1 | 2/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2080915 | 0.97 | MAPK14 (0.60) | MAPK14MAPK13MAPK12MAPK11CCNT1 | |
| SCHEMBL2080167 | 0.95 | MAPK14 (0.68) | MAPK14MAPK13MAPK12MAPK11CCNT1 | |
| SCHEMBL2079157 | 0.89 | MAPK14 (0.56) | MAPK14MAPK13MAPK12MAPK11CCNT1 | |
| SCHEMBL4255507 | 0.83 | MAPK14 (0.47) | MAPK14MAPK13MAPK12MAPK11ATR | |
| SCHEMBL2079373 | 0.82 | MAPK14 (0.68) | MAPK14MAPK13MAPK12MAPK11CCNT1 | |
| SCHEMBL2079128 | 0.82 | MAPK14 (0.56) | MAPK14MAPK13MAPK12MAPK11ATR | |
| SCHEMBL2080009 | 0.80 | MAPK14 (0.85) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL2079289 | 0.79 | MAPK14 (0.58) | MAPK14MAPK13MAPK12MAPK11CCNT1 | |
| SCHEMBL2080714 | 0.78 | CCNT1 (0.51) | MAPK14CCNT1 | |
| SCHEMBL4069271 | 0.77 | MAPK14 (0.45) | MAPK14MAPK13MAPK12MAPK11ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049537-A1 | 1, 7-NAPHTHYRIDINE DERIVATIVES AS P38 MAP KINASE INHIBITORS | Laboratorios Almirall, S.A. (ES) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008017461-A1 | 1, 7-NAPHTHYRIDINE DERIVATIVES AS P38 MAP KINASE INHIBITORS | LABORATORIOS ALMIRALL, S.A. (ES) | 2008-02-14 | — | — | WO | disclosed |