Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 14/20 | 0.60 |
| ▸ | ADORA1 | P30542 | 14/20 | 0.60 |
| ▸ | ADORA2A | P29274 | 13/20 | 0.60 |
| ▸ | ADORA2B | P29275 | 9/20 | 0.52 |
| ▸ | PI4KA | P42356 | 1/20 | 0.52 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.52 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.52 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4062627 | 0.91 | ADORA3 (0.55) | ADORA3ADORA1ADORA2AADORA2BPI4KA | |
| SCHEMBL4066247 | 0.88 | ADORA3 (0.57) | ADORA3ADORA1ADORA2AADORA2BPI4KA | |
| SCHEMBL4067321 | 0.88 | ADORA3 (0.57) | ADORA3ADORA1ADORA2AADORA2BPI4KA | |
| SCHEMBL783764 | 0.88 | ADORA3 (0.68) | ADORA3ADORA1ADORA2AADORA2BPI4KA | |
| SCHEMBL6659013 | 0.85 | ADORA3 (0.48) | ADORA3ADORA1ADORA2AADORA2BPI4KA | |
| SCHEMBL4058506 | 0.85 | ADORA3 (0.59) | ADORA3ADORA1ADORA2AADORA2BPI4KA | |
| SCHEMBL4064370 | 0.83 | ADORA1 (0.60) | ADORA3ADORA1ADORA2AADORA2BPI4KA | |
| SCHEMBL6666123 | 0.83 | PIK3CD (0.51) | ADORA3ADORA1ADORA2AADORA2BPI4KA | |
| SCHEMBL6662360 | 0.83 | ADORA3 (0.46) | ADORA3ADORA1ADORA2AADORA2BPI4KA | |
| SCHEMBL19426740 | 0.83 | ADORA3 (0.47) | ADORA3ADORA1ADORA2AADORA2BPI4KA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7517888-B2 | e.g. cyclopentyl(9-ethyl-8-phenylpurin-6-yl)amine; diuretic; heart failure, chronic renal disease, cirrhosis | CV THERAPEUTICS, INC. (US) | 2009-04-14 | — | — | US | disclosed |
| EP-1751159-A2 | PURINE DERIVATIVES AS A1 ADENOSINE RECEPTOR ANTAGONISTS | CV THERAPEUTICS, INC. (US) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005105803-A2 | PURINE DERIVATIVES AS A1 ADENOSINE RECEPTOR ANTAGONISTS | CV THERAPEUTICS, INC. (US) | 2005-11-10 | — | — | WO | disclosed |
| US-20050245546-A1 | A1 adenosine receptor antagonists | CV THERAPEUTICS, INC. | 2005-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245546-A1 | A1 adenosine receptor antagonists | ADORA1, ADORA2A, ADORA3 | ADORA3 3/4885ADORA1 1/4885ADORA2A 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.