Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 6/20 | 0.52 |
| ▸ | THRA | P10827 | 4/20 | 0.52 |
| ▸ | THRB | P10828 | 4/20 | 0.52 |
| ▸ | DHODH | Q02127 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CDK9 | P50750 | 2/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.46 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PHLPP2 | Q6ZVD8 | 2/20 | 0.42 |
| ▸ | ALPG | P10696 | 1/20 | 0.41 |
| ▸ | BBOX1 | O75936 | 3/20 | 0.41 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4075079 | 0.94 | DHODH (0.49) | EGLN1THRATHRBDHODHKDM4E | |
| SCHEMBL523239 | 0.86 | EGLN1 (0.50) | EGLN1THRATHRBKDM4EALDH1A1 | |
| SCHEMBL31028941 | 0.83 | THRA (0.76) | EGLN1THRATHRBBBOX1FTO | |
| SCHEMBL523344 | 0.83 | THRA (0.76) | EGLN1THRATHRBBBOX1FTO | |
| SCHEMBL8139266 | 0.83 | THRA (0.50) | EGLN1THRATHRBDHODHKDM4E | |
| SCHEMBL8134005 | 0.83 | THRA (0.50) | EGLN1THRATHRBDHODHKDM4E | |
| SCHEMBL522422 | 0.81 | EGLN1 (0.45) | EGLN1THRATHRBKDM4EALDH1A1 | |
| SCHEMBL4069669 | 0.81 | DHODH (0.44) | EGLN1THRATHRBDHODHKDM4E | |
| SCHEMBL8134048 | 0.80 | THRA (0.58) | EGLN1THRATHRBBBOX1FTO | |
| SCHEMBL522615 | 0.79 | EGLN1 (0.55) | EGLN1THRATHRBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1538160-B1 | Substituted Isoquinolin-3-carboxyamides, their preparation and medical use | FIBROGEN INC (US) | 2009-06-03 | — | — | EP | disclosed |
| EP-0911340-B1 | Substituted Isoquinolin-3-Carboxyamides, their preparation and medical use | FIBROGEN INC (US) | 2005-07-06 | — | — | EP | disclosed |
| EP-1538160-A1 | Substituted Isoquinolin-3-carboxyamides, their preparation and medical use | FIBROGEN, INC. (US) | 2005-06-08 | — | — | EP | disclosed |
| US-6093730-A | AN ENZYME INHIBITORS OF PROLYL-4-HYDROXYLASE FOR TREATING FIBROTIC DISORDERS AND INHIBITING COLLAGEN BIOSYNTHESIS | HOECHST MARION ROUSSEL DEUTSCHLAND GMBH (DE) | 2000-07-25 | — | — | US | disclosed |
| EP-0911340-A2 | Substituted Isoquinolin-3-Carboxyamides, their preparation and medical use | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-04-28 | — | — | EP | disclosed |