Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 19/20 | 0.57 |
| ▸ | CCND1 | P24385 | 18/20 | 0.57 |
| ▸ | CCND3 | P30281 | 14/20 | 0.57 |
| ▸ | CCND2 | P30279 | 10/20 | 0.57 |
| ▸ | CDK2 | P24941 | 6/20 | 0.56 |
| ▸ | CDK6 | Q00534 | 6/20 | 0.53 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.53 |
| ▸ | CDK9 | P50750 | 5/20 | 0.53 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.53 |
| ▸ | CDK7 | P50613 | 4/20 | 0.53 |
| ▸ | CCNH | P51946 | 4/20 | 0.53 |
| ▸ | CDK1 | P06493 | 3/20 | 0.53 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.53 |
| ▸ | SYK | P43405 | 1/20 | 0.51 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.50 |
| ▸ | CCNT2 | O60583 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
| ▸ | STK16 | O75716 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4073787 | 0.93 | CDK4 (0.51) | CDK4CCND1CCND3CCND2CDK2 | |
| SCHEMBL4075543 | 0.93 | SYK (0.53) | CDK4CCND1CCND3CCND2CDK2 | |
| SCHEMBL4066054 | 0.88 | CDK4 (0.67) | CDK4CCND1CCND3CCND2CDK2 | |
| Hydrochloric Acid SCHEMBL4066040 | 0.87 | CDK4 (0.67) | CDK4CCND1CCND3CCND2CDK2 | |
| SCHEMBL4071475 | 0.87 | SYK (0.49) | CDK4CCND1CCND3CCND2CDK2 | |
| SCHEMBL4070689 | 0.84 | CDK4 (0.55) | CDK4CCND1CCND3CCND2CDK2 | |
| SCHEMBL4071249 | 0.83 | CDK4 (0.56) | CDK4CCND1CCND3CCND2CDK2 | |
| SCHEMBL4074950 | 0.83 | CDK4 (0.56) | CDK4CCND1CCND3CCND2CDK2 | |
| SCHEMBL4076077 | 0.82 | SYK (0.61) | CDK4CCND1CCND3CCND2CDK2 | |
| SCHEMBL4067757 | 0.82 | CDK4 (0.64) | CDK4CCND1CCND3CCND2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1590341-B1 | 2-AMINOPYRIDINE SUBSTITUTED HETEROCYCLES AS INHIBITORS OF CELLULAR PROLIFERATION | WARNER LAMBERT CO (US) | 2009-06-17 | — | — | EP | claimed |