SCHEMBL4070689

SCHEMBL4070689

CCOC(=O)Oc1cnc(Nc2ccc(N3CCNCC3)cn2)nc1N

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK4 P11802 15/20 0.55
CCND1 P24385 13/20 0.55
CCND3 P30281 11/20 0.55
CCND2 P30279 8/20 0.55
CDK2 P24941 4/20 0.53
CCNA2 P20248 3/20 0.49
CDK6 Q00534 3/20 0.49
CCNK O75909 2/20 0.49
CDK9 P50750 2/20 0.49
CHEK1 O14757 1/20 0.47
DAPK3 O43293 1/20 0.47
CCNT1 O60563 1/20 0.47
CCNT2 O60583 1/20 0.47
ROCK2 O75116 1/20 0.47
STK16 O75716 1/20 0.47
PDE5A O76074 1/20 0.47
PRKD3 O94806 1/20 0.47
CCNB2 O95067 1/20 0.47
ABCB11 O95342 1/20 0.47
MAP4K4 O95819 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4069536 0.92 CDK4 (0.54) CDK4CCND1CCND3CCND2CDK2
SCHEMBL4073235 0.86 CDK4 (0.64) CDK4CCND1CCND3CCND2CDK2
SCHEMBL4069730 0.84 CDK4 (0.57) CDK4CCND1CCND3CCND2CDK2
SCHEMBL4068763 0.81 CDK4 (0.53) CDK4CCND1CCND3CCND2CDK2
SCHEMBL4068767 0.81 CDK4 (0.53) CDK4CCND1CCND3CCND2CDK2
SCHEMBL13812807 0.80 CDK4 (0.64) CDK4CCND1CCND3CCND2CDK2
SCHEMBL4066350 0.80 CDK4 (0.56) CDK4CCND1CCND3CCND2CDK2
SCHEMBL4065441 0.79 CDK4 (0.61) CDK4CCND1CCND3CCND2CDK2
Hydrochloric Acid SCHEMBL6222758 0.78 CDK4 (0.81) CDK4CCND1CCND3CCND2CDK2
SCHEMBL4068504 0.77 PTK2 (0.46) CDK4CCND1CCND3CCND2CDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1590341-B1 2-AMINOPYRIDINE SUBSTITUTED HETEROCYCLES AS INHIBITORS OF CELLULAR PROLIFERATION WARNER LAMBERT CO (US) 2009-06-17 EP claimed