Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 6/20 | 0.58 |
| ▸ | IGF1R | P08069 | 2/20 | 0.55 |
| ▸ | CA2 | P00918 | 4/20 | 0.54 |
| ▸ | CDK1 | P06493 | 6/20 | 0.53 |
| ▸ | KDR | P35968 | 6/20 | 0.53 |
| ▸ | CDK2 | P24941 | 5/20 | 0.53 |
| ▸ | CDK4 | P11802 | 2/20 | 0.53 |
| ▸ | CDK7 | P50613 | 2/20 | 0.53 |
| ▸ | CDK9 | P50750 | 2/20 | 0.53 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.53 |
| ▸ | CCND1 | P24385 | 1/20 | 0.53 |
| ▸ | CCNH | P51946 | 1/20 | 0.53 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.52 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.52 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.48 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.46 |
| ▸ | STK16 | O75716 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4070220 | 1.00 | SYK (0.58) | SYKIGF1RCA2CDK1KDR | |
| SCHEMBL4058413 | 0.85 | SYK (0.69) | SYKIGF1RCA2CDK1KDR | |
| SCHEMBL4064533 | 0.85 | SYK (0.69) | SYKIGF1RCA2CDK1KDR | |
| SCHEMBL4068789 | 0.85 | SYK (0.68) | SYKIGF1RCA2CDK1KDR | |
| SCHEMBL4580306 | 0.84 | CDK1 (0.44) | SYKIGF1RCA2CDK1KDR | |
| SCHEMBL14000045 | 0.84 | CDK1 (0.44) | SYKIGF1RCA2CDK1KDR | |
| SCHEMBL4070462 | 0.83 | SYK (0.69) | SYKIGF1RCA2CDK1KDR | |
| SCHEMBL4068613 | 0.83 | SYK (0.62) | SYKIGF1RCA2CDK1KDR | |
| SCHEMBL14498929 | 0.83 | SYK (0.69) | SYKIGF1RCA2CDK1KDR | |
| SCHEMBL13648587 | 0.83 | SYK (0.69) | SYKIGF1RCA2CDK1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392662-B1 | CDK INHIBITING PYRIMIDINES, PRODUCTION THEREOF AND THEIR USE AS MEDICAMENTS | BAYER SCHERING PHARMA AG (DE) | 2009-01-07 | — | — | EP | claimed |
| EP-1392662-B1 | CDK INHIBITING PYRIMIDINES, PRODUCTION THEREOF AND THEIR USE AS MEDICAMENTS | BAYER SCHERING PHARMA AG (DE) | 2009-01-07 | — | — | EP | disclosed |