Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 13/20 | 0.58 |
| ▸ | EGLN2 | Q96KS0 | 18/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL523399 | 0.90 | EGLN1 (0.71) | EGLN1EGLN2 | |
| SCHEMBL8146957 | 0.88 | EGLN1 (0.69) | EGLN1EGLN2 | |
| SCHEMBL8141355 | 0.86 | EGLN1 (0.71) | EGLN1EGLN2 | |
| SCHEMBL4071786 | 0.83 | THRA (0.59) | EGLN1POLB | |
| SCHEMBL4075055 | 0.82 | EGLN2 (0.52) | EGLN1EGLN2 | |
| SCHEMBL4081668 | 0.81 | EGLN1 (0.59) | EGLN1EGLN2 | |
| SCHEMBL8146026 | 0.81 | EGLN1 (0.49) | EGLN1EGLN2 | |
| SCHEMBL23269740 | 0.81 | EGLN1 (0.77) | EGLN1EGLN2 | |
| SCHEMBL29956293 | 0.81 | EGLN1 (0.77) | EGLN1EGLN2 | |
| SCHEMBL3780789 | 0.80 | EGLN1 (0.79) | EGLN1EGLN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1538160-B1 | Substituted Isoquinolin-3-carboxyamides, their preparation and medical use | FIBROGEN INC (US) | 2009-06-03 | — | — | EP | disclosed |
| EP-0911340-B1 | Substituted Isoquinolin-3-Carboxyamides, their preparation and medical use | FIBROGEN INC (US) | 2005-07-06 | — | — | EP | disclosed |
| EP-1538160-A1 | Substituted Isoquinolin-3-carboxyamides, their preparation and medical use | FIBROGEN, INC. (US) | 2005-06-08 | — | — | EP | disclosed |
| EP-0911340-A2 | Substituted Isoquinolin-3-Carboxyamides, their preparation and medical use | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-04-28 | — | — | EP | disclosed |