Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 9/20 | 0.45 |
| ▸ | CDK6 | Q00534 | 8/20 | 0.45 |
| ▸ | CCND1 | P24385 | 7/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.45 |
| ▸ | CDK2 | P24941 | 6/20 | 0.45 |
| ▸ | CCND3 | P30281 | 6/20 | 0.45 |
| ▸ | CDK1 | P06493 | 5/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.45 |
| ▸ | CDK7 | P50613 | 5/20 | 0.45 |
| ▸ | CCNH | P51946 | 5/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.44 |
| ▸ | CDK9 | P50750 | 4/20 | 0.44 |
| ▸ | SYK | P43405 | 10/20 | 0.44 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.42 |
| ▸ | CTSC | P53634 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4068785 | 0.90 | AURKA (0.46) | CDK4CDK6CCND1CCNA2CDK2 | |
| SCHEMBL4073699 | 0.90 | SYK (0.51) | CDK4CDK6CCND1CCNA2CDK2 | |
| SCHEMBL4072937 | 0.89 | SYK (0.51) | CDK4CDK6CCND1CCNA2CDK2 | |
| SCHEMBL4182326 | 0.83 | SYK (0.51) | CDK4CDK6CCND1CCNA2CDK2 | |
| SCHEMBL4066359 | 0.79 | SYK (0.57) | CDK4CDK6CCND1CCNA2CDK2 | |
| SCHEMBL4065141 | 0.79 | CDK4 (0.56) | CDK4CDK6CCND1CCNA2CDK2 | |
| SCHEMBL4065950 | 0.79 | SYK (0.53) | CDK4CDK6CCND1CCNA2CDK2 | |
| SCHEMBL4071068 | 0.79 | SYK (0.51) | CDK4CDK6CCND1CCNA2CDK2 | |
| SCHEMBL4063982 | 0.78 | SYK (0.56) | CDK4CDK6CCND1CCNA2CDK2 | |
| SCHEMBL6222101 | 0.77 | CDK4 (0.66) | CDK4CCND1CCNA2CDK2CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1590341-B1 | 2-AMINOPYRIDINE SUBSTITUTED HETEROCYCLES AS INHIBITORS OF CELLULAR PROLIFERATION | WARNER LAMBERT CO (US) | 2009-06-17 | — | — | EP | claimed |