SCHEMBL4072937 — predicted protein targets

Predicted protein targets (top 14)

	gene	UniProt	supporting neighbours	confidence
▸	SYK	P43405	15/20	0.51

▸	CDK4	P11802	5/20	0.47

▸	CCND1	P24385	5/20	0.47

▸	CCND3	P30281	4/20	0.47

▸	CCNA2	P20248	3/20	0.47

▸	CDK2	P24941	3/20	0.47

▸	CDK6	Q00534	3/20	0.47

▸	CDK1	P06493	2/20	0.47

▸	CCNB1	P14635	2/20	0.47

▸	CDK7	P50613	2/20	0.47

▸	CCNH	P51946	2/20	0.47

▸	CCNT1	O60563	2/20	0.46

▸	CDK9	P50750	2/20	0.46

▸	CCND2	P30279	1/20	0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL4068785	0.90	AURKA (0.46)	SYKCDK4CCND1CCND3CCNA2
SCHEMBL4063982	0.90	SYK (0.56)	SYKCDK4CCND1CCND3CCNA2
SCHEMBL4070490	0.89	CDK4 (0.45)	SYKCDK4CCND1CCND3CCNA2
SCHEMBL4067757	0.82	CDK4 (0.64)	SYKCDK4CCND1CCND3CCNA2
SCHEMBL4071155	0.81	SYK (0.53)	SYKCDK4CCND1CCND3CCNA2
SCHEMBL4071154	0.81	SYK (0.53)	SYKCDK4CCND1CCND3CCNA2
SCHEMBL4068180	0.80	SYK (0.53)	SYKCDK4CCND1CCND3CCNA2
SCHEMBL4071068	0.79	SYK (0.51)	SYKCDK4CCND1CCND3CCNA2
SCHEMBL4065950	0.79	SYK (0.53)	SYKCDK4CCND1CCND3CCNA2
SCHEMBL4073699	0.78	SYK (0.51)	SYKCDK4CCND1CCND3CCNA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-1590341-B1	2-AMINOPYRIDINE SUBSTITUTED HETEROCYCLES AS INHIBITORS OF CELLULAR PROLIFERATION	WARNER LAMBERT CO (US)	2009-06-17	—	—	EP	claimed