Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 9/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | THRA | P10827 | 3/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4070630 | 0.85 | THRB (0.41) | THRBHSP90AA1ALDH1A1USP2LMNA | |
| SCHEMBL3226077 | 0.81 | THRB (0.38) | THRBHSP90AA1ALDH1A1THRANPSR1 | |
| SCHEMBL3226755 | 0.80 | THRB (0.41) | THRBHSP90AA1ALDH1A1USP2LMNA | |
| SCHEMBL13044566 | 0.79 | THRB (0.48) | THRBHSP90AA1ALDH1A1USP2LMNA | |
| SCHEMBL6659752 | 0.78 | THRB (0.49) | THRBHSP90AA1ALDH1A1THRA | |
| SCHEMBL13381911 | 0.75 | THRB (0.49) | THRBHSP90AA1ALDH1A1THRA | |
| SCHEMBL6218620 | 0.74 | THRB (0.75) | THRBTHRA | |
| SCHEMBL3232843 | 0.73 | MAPT (0.37) | THRBHSP90AA1ALDH1A1USP2LMNA | |
| SCHEMBL16495910 | 0.69 | HSP90AA1 (0.39) | THRBHSP90AA1ALDH1A1THRANPSR1 | |
| SCHEMBL16495912 | 0.69 | HSP90AA1 (0.39) | THRBHSP90AA1ALDH1A1THRANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079678-A2 | SELECTIVE TR-BETA 1 AGONIST | Cadila Healthcare Limited (IN) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008062469-A2 | SELECTIVE TR-BETA 1 AGONIST | CADILA HEALTHCARE LIMITED (IN) | 2008-05-29 | — | — | WO | disclosed |