Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | STS | P08842 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | TERT | O14746 | 1/20 | 0.37 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.37 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.37 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4080093 | 0.88 | GPR119 (0.36) | USP30GPR119JAK2JAK1STS | |
| SCHEMBL4069724 | 0.85 | USP30 (0.36) | USP30GPR119JAK2JAK1KDM4E | |
| SCHEMBL3332874 | 0.80 | USP30 (0.45) | USP30GPR119JAK2JAK1KDM4E | |
| SCHEMBL3329651 | 0.80 | USP30 (0.45) | USP30GPR119JAK2JAK1KDM4E | |
| SCHEMBL3329274 | 0.80 | USP30 (0.45) | USP30GPR119JAK2JAK1KDM4E | |
| SCHEMBL3185439 | 0.80 | USP30 (0.45) | USP30GPR119JAK2JAK1KDM4E | |
| SCHEMBL5298248 | 0.79 | SLC6A2 (0.41) | USP30GPR119KDM4EPKMSMARCA2 | |
| SCHEMBL5298242 | 0.79 | SLC6A2 (0.41) | USP30GPR119KDM4EPKMSMARCA2 | |
| SCHEMBL5298240 | 0.79 | SLC6A2 (0.41) | USP30GPR119KDM4EPKMSMARCA2 | |
| SCHEMBL1552545 | 0.78 | KDM1A (0.41) | KDM1AUSP30GPR119JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716126-B1 | MORPHOLINE DERIVATIVES AS NOREPINEPHRINE REUPTAKE INHIBITORS | LILLY CO ELI (US) | 2009-02-25 | — | — | EP | disclosed |