Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Triamterene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | MTOR | P42345 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | JAK2 | O60674 | 1/20 | 1.00 |
| ▸ | GMNN | O75496 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | GLA | P06280 | 1/20 | 1.00 |
| ▸ | CTSG | P08311 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | GAA | P10253 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | PKM | P14618 | 1/20 | 1.00 |
| ▸ | HPGD | P15428 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | ALOX12 | P18054 | 1/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Triamterene SCHEMBL5421685 | 1.00 | ALDH1A1 (1.00) | ALDH1A1MTORKDM4EJAK2GMNN | |
| Triamterene SCHEMBL29531410 | 1.00 | ALDH1A1 (1.00) | ALDH1A1MTORKDM4EJAK2GMNN | |
| Triamterene SCHEMBL11044581 | 0.98 | ALDH1A1 (0.97) | ALDH1A1MTORKDM4EJAK2GMNN | |
| SCHEMBL10894514 | 0.93 | ALDH1A1 (0.87) | ALDH1A1MTORKDM4EJAK2GMNN | |
| SCHEMBL3746280 | 0.91 | PIK3CG (1.00) | ALDH1A1MTORKDM4EJAK2GMNN | |
| Triamterene SCHEMBL11405508 | 0.87 | ALDH1A1 (0.76) | ALDH1A1MTORKDM4EJAK2GMNN | |
| SCHEMBL10567039 | 0.86 | ALDH1A1 (0.75) | ALDH1A1MTORKDM4EJAK2GMNN | |
| SCHEMBL9682028 | 0.85 | PIK3CG (0.76) | ALDH1A1MTORKDM4EJAK2GMNN | |
| SCHEMBL6061478 | 0.85 | PIK3CG (0.76) | ALDH1A1MTORKDM4EJAK2GMNN | |
| SCHEMBL10568940 | 0.84 | MTOR (0.71) | ALDH1A1MTORKDM4EJAK2GMNN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 23336 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4747611-A1 | OPTICAL ELECTRODE ANALYTE DETECTION SYSTEM AND METHODS OF USE | Vital Biosciences Inc. (CA) | 2026-05-27 | — | — | EP | claimed |
| WO-2026106917-A1 | EDIBLE TRANSMUCOSAL DRUG DELIVERY METHOD USING AN INTERMEDIATE CAPSULE AS A TEMPORARY VESSEL | BioPhysics Pharma, Inc. (US) | 2026-05-21 | — | — | WO | claimed |
| US-20260115166-A1 | COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF PHOTORECEPTOR ROD DEGENERATIONS AND GENERATION OF PHOTORECEPTORS | PURDUE RESEARCH FOUNDATION (US) | 2026-04-30 | — | — | US | claimed |
| WO-2026087680-A1 | TREATMENT FOR CARDIOVASCULAR DISEASE | SAPREME TECHNOLOGIES B.V. (NL) | 2026-04-30 | — | — | WO | claimed |
| WO-2026087695-A1 | TREATMENT FOR METABOLIC DISORDER | SAPREME TECHNOLOGIES B.V. (NL) | 2026-04-30 | — | — | WO | claimed |
| US-12605345-B2 | Transdermal drug delivery system | BioPhysics Pharma, Inc. (US) | 2026-04-21 | — | — | US | claimed |
| EP-4722714-A1 | SIMULTANEOUS ANALYSIS OF FOOD-BORNE DOPING SUBSTANCES USING LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY (VFD: VACCINE FOR FOODBORNE DOPING) | Korea Institute of Science and Technology (KR) | 2026-04-08 | — | — | EP | claimed |
| EP-4710928-A2 | METHODS OF TREATING IGA NEPHROPATHY WITH ATRASENTAN | Chinook Therapeutics, Inc. (US) | 2026-03-18 | — | — | EP | claimed |
| US-20260028675-A1 | PRECISION MEDICINE FOR PAIN: DIAGNOSTIC BIOMARKERS, PHARMACOGENOMICS, AND REPURPOSED DRUGS | UNIV INDIANA RES & TECH CORP (US) | 2026-01-29 | — | — | US | claimed |
| US-20250352511-A1 | METHODS OF TREATING FOCAL SEGMENTAL GLOMERULOSCLEROSIS WITH ATRASENTAN | CHINOOK THERAPEUTICS INC (US) | 2025-11-20 | — | — | US | claimed |
| US-4285947-A | DIURETICS, HYPOTENSIVES | INTERX RESEARCH CORPORATION (US) | 1981-08-25 | — | — | US | claimed |
| EP-0032725-A1 | Novel aldehyde adducts of triamterene and a pharmaceutical composition containing the same | MERCK & CO. INC. (US) | 1981-07-29 | — | — | EP | claimed |
| US-4255413-A | WITH A SURFACTANT AND A CARBONATE OR BICARBONATE SALT AS DILUENTS | SMITHKLINE CORPORATION (US) | 1981-03-10 | — | — | US | claimed |
| US-4248857-A | PROPRANOLOL AND SUGAR COATING ON A CORE OF PROPRANOLOL, POLYACRYLIC ACID, STEARIC ACID AND MANNITOL; ENERGIC BLOCKING AGENT | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-02-03 | — | — | US | claimed |
| US-4248856-A | COMPRISING A CELLULOSIC CORE, SUGAR COATING AND HAVING PROPRANOLOL IN BOTH | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-02-03 | — | — | US | claimed |
| US-4247550-A | Compositions and methods for the treatment of hypertension or oedemas | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) | 1981-01-27 | — | — | US | claimed |
| EP-0022330-A2 | Synergistic antihypertensive compositions | SMITHKLINE BECKMAN CORPORATION (US) | 1981-01-14 | — | — | EP | claimed |
| US-4217347-A | MERCAPTOALKYL ALKANOYLPROLINES AND A DIURETIC | E. R. SQUIBB & SONS, INC. (US) | 1980-08-12 | — | — | US | claimed |
| US-4157394-A | Cardio-protective pharmaceutical composition | ROHM PHARMA GMBH (DE) | 1979-06-05 | — | — | US | claimed |
| US-4056618-A | TRIAMTERENE AND CYCLOTHIAZIDE | ROUSSEL-UCLAF (FR) | 1977-11-01 | — | — | US | claimed |