Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | RPS6KA5 | O75582 | 5/20 | 0.39 |
| ▸ | AKT1 | P31749 | 4/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.39 |
| ▸ | AKT2 | P31751 | 3/20 | 0.39 |
| ▸ | AKT3 | Q9Y243 | 3/20 | 0.39 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 2/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4065699 | 0.86 | KDM4E (0.41) | SLC2A1RPS6KA5AKT1ROCK1AKT2 | |
| Trifluoroacetic Acid SCHEMBL5066248 | 0.83 | SLC2A1 (0.45) | SLC2A1RPS6KA5AKT1ROCK1AKT2 | |
| SCHEMBL4066084 | 0.82 | RPS6KA5 (0.57) | SLC2A1RPS6KA5AKT1ROCK1AKT2 | |
| Hydrochloric Acid SCHEMBL5066396 | 0.81 | RPS6KA5 (0.56) | SLC2A1RPS6KA5AKT1ROCK1AKT2 | |
| SCHEMBL4072215 | 0.81 | SLC2A1 (0.56) | SLC2A1RPS6KA5AKT1ROCK1AKT2 | |
| SCHEMBL4065044 | 0.77 | AKT1 (0.58) | SLC2A1RPS6KA5AKT1ROCK1AKT2 | |
| SCHEMBL4065048 | 0.76 | RPS6KA5 (0.47) | SLC2A1RPS6KA5AKT1ROCK1AKT2 | |
| SCHEMBL4073102 | 0.76 | SLC2A1 (0.65) | SLC2A1RPS6KA5AKT1ROCK1AKT2 | |
| SCHEMBL4061014 | 0.76 | AKT1 (0.56) | SLC2A1RPS6KA5AKT1ROCK1AKT2 | |
| SCHEMBL4071929 | 0.75 | RPS6KA5 (0.55) | SLC2A1RPS6KA5AKT1ROCK1AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080255143-A1 | Inhibitors of Akt Activity | SMITHKLINE BEECHAM CORPORATION (PA) | 2008-10-16 | — | — | US | claimed |
| EP-1653961-A4 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORP (US) | 2009-04-01 | — | — | EP | disclosed |
| US-20080255143-A1 | Inhibitors of Akt Activity | SMITHKLINE BEECHAM CORPORATION (PA) | 2008-10-16 | — | — | US | disclosed |
| EP-1653961-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005011700-A1 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2005-02-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255143-A1 | Inhibitors of Akt Activity | PI4KB, PIK3CA, AKT2 | SLC2A1 3039/4885FYN 292/4885RPS6KA5 156/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.