Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 3/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | AKT1 | P31749 | 3/20 | 0.36 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.36 |
| ▸ | AKT2 | P31751 | 2/20 | 0.36 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.36 |
| ▸ | CTSG | P08311 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4065699 | 0.96 | KDM4E (0.41) | SLC2A1KDM4EKMT2AMAPK1ROCK1 | |
| SCHEMBL5597324 | 0.88 | KDM4E (0.39) | KDM4EKMT2AMAPK1TP53MAPT | |
| SCHEMBL4070786 | 0.83 | SLC2A1 (0.39) | SLC2A1MAPK1ROCK1PRKACARPS6KB1 | |
| Trifluoroacetic Acid SCHEMBL5063614 | 0.78 | AKT1 (0.54) | SLC2A1ROCK1PRKACARPS6KB1GSK3B | |
| SCHEMBL4067994 | 0.77 | AKT1 (0.50) | SLC2A1KDM4EKMT2AROCK1THRB | |
| SCHEMBL4072215 | 0.76 | SLC2A1 (0.56) | SLC2A1ROCK1PRKACARPS6KB1GSK3B | |
| Trifluoroacetic Acid SCHEMBL4252172 | 0.75 | SLC2A1 (0.73) | SLC2A1ROCK1PRKACAGSK3BAKT1 | |
| Trifluoroacetic Acid SCHEMBL5062962 | 0.75 | SLC2A1 (0.62) | SLC2A1ATMROCK1PRKACAGSK3B | |
| SCHEMBL5066259 | 0.75 | KDM4E (0.38) | KDM4EKMT2AMAPK1THRBTP53 | |
| Trifluoroacetic Acid SCHEMBL5062992 | 0.74 | AKT1 (0.43) | SLC2A1ATMROCK1AKT1RPS6KA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080255143-A1 | Inhibitors of Akt Activity | SMITHKLINE BEECHAM CORPORATION (PA) | 2008-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255143-A1 | Inhibitors of Akt Activity | PI4KB, PIK3CA, AKT2 | SLC2A1 3039/4885KDM4E 2078/4885KMT2A 1852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.