SCHEMBL4070802

SCHEMBL4070802

N[N+]12C=CN=CC1=C(C1CC(O)C1)N=C2c1ccc2ccc(Oc3ccccc3)nc2c1Cl

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PIM1 P11309 2/20 0.31
PIM2 Q9P1W9 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL396742 0.90 PIM1 (0.31) PIM1PIM2
SCHEMBL4065777 0.87 TNK2 (0.34) PIM1PIM2
SCHEMBL4067736 0.86 IGF1R (0.30)
SCHEMBL4071108 0.86 TNK2 (0.34)
SCHEMBL399371 0.85
SCHEMBL4067696 0.84 PIM1 (0.31) PIM1PIM2
SCHEMBL4067756 0.82
SCHEMBL4066073 0.82
SCHEMBL400085 0.81 TNK2 (0.31)
SCHEMBL402006 0.81 KDM4E (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1740591-B1 6,6-BICYCLIC RING SUBSTITUTED HETEROBICYCLIC PROTEIN KINASE INHIBITORS OSI PHARM INC (US) 2009-06-17 EP claimed