Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | NPY1R | P25929 | 1/20 | 0.43 |
| ▸ | NPY2R | P49146 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.42 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4061813 | 0.94 | ALDH1A1 (0.49) | ERN1ALDH1A1MDM2LMNAMAOB | |
| SCHEMBL4070043 | 0.94 | ALDH1A1 (0.49) | ERN1ALDH1A1MDM2LMNAMAOB | |
| SCHEMBL5449064 | 0.93 | MDM2 (0.52) | ERN1ALDH1A1MDM2MAOBMEN1 | |
| SCHEMBL4067770 | 0.90 | MDM2 (0.50) | ERN1ALDH1A1MDM2MAOBMEN1 | |
| SCHEMBL1125718 | 0.90 | ALDH1A1 (0.55) | ERN1ALDH1A1LMNAMAOBMAPT | |
| SCHEMBL20892596 | 0.87 | ALDH1A1 (0.67) | ERN1ALDH1A1MDM2MAOBMEN1 | |
| SCHEMBL4064858 | 0.87 | ALDH1A1 (0.51) | ERN1ALDH1A1MDM2LMNAMAOB | |
| SCHEMBL5106446 | 0.84 | MAOB (0.50) | ALDH1A1MDM2MAOBHPGDHTT | |
| SCHEMBL20892674 | 0.84 | ALDH1A1 (0.67) | ERN1ALDH1A1MDM2LMNAMAOB | |
| SCHEMBL22322045 | 0.84 | ALDH1A1 (0.49) | ERN1ALDH1A1LMNAMAOBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1852883-B | Alpha-hydroxy-benzeneacetic acid derivatives, and compounds having two 5-membered lactone rings fused to central cyclohexa-1,4-diene nucleus based upon the same, and uses of the compounds | KYUNG IN SYNTHETIC CORP | 2010-05-05 | — | — | CN | disclosed |
| US-7632830-B2 | Lactam compounds and pharmaceutical use thereof | AJINOMOTO CO., INC. (JP) | 2009-12-15 | — | — | US | disclosed |
| EP-1346993-B1 | LACTAM COMPOUNDS AND MEDICAL USE THEREOF | AJINOMOTO KK (JP) | 2009-10-21 | — | — | EP | disclosed |
| US-20080096862-A1 | LACTAM COMPOUNDS AND PHARMACEUTICAL USE THEREOF | AJINOMOTO CO., INC. (JP) | 2008-04-24 | — | — | US | disclosed |
| US-7326701-B2 | Lactam compounds and pharmaceutical use thereof | AJINOMOTO CO., INC. (JP) | 2008-02-05 | — | — | US | disclosed |
| US-7153850-B2 | Lactam compounds and pharmaceutical use thereof | AJINOMOTO CO., INC. (JP) | 2006-12-26 | — | — | US | disclosed |
| CN-1852883-A | Alpha-hydroxy-benzeneacetic acid derivatives, and compounds having two 5-membered lactone rings fused to central cyclohexa-1,4-diene nucleus based upon the same, and uses of the compounds | KYUNG IN SYNTHETIC CORP (KR) | 2006-10-25 | — | — | CN | disclosed |
| US-20060189597-A1 | Lactam compounds and pharmaceutical use thereof | AJINOMOTO CO., INC. (JP) | 2006-08-24 | — | — | US | disclosed |
| US-20040048847-A1 | Lactam compounds and pharmaceutical use thereof | AJINOMOTO CO. INC (JP) | 2004-03-11 | — | — | US | disclosed |
| EP-1346993-A1 | LACTAM COMPOUNDS AND MEDICINAL USE THEREOF | Ajinomoto Co., Inc. (JP) | 2003-09-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060189597-A1 | Lactam compounds and pharmaceutical use thereof | SLC2A4, SLC2A8, SLC2A1 | ERN1 2414/4885ALDH1A1 911/4885MDM2 1501/4885 |
| US-20040048847-A1 | Lactam compounds and pharmaceutical use thereof | SLC2A4, SLC2A8, SLC2A1 | ERN1 2414/4885ALDH1A1 911/4885MDM2 1501/4885 |
| US-20080096862-A1 | LACTAM COMPOUNDS AND PHARMACEUTICAL USE THEREOF | SLC2A4, SLC2A8, SLC2A1 | ERN1 2414/4885ALDH1A1 911/4885MDM2 1501/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.