Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 9/20 | 0.46 |
| ▸ | CNR1 | P21554 | 6/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.38 |
| ▸ | USP36 | Q9P275 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | WNT1 | P04628 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4069777 | 0.94 | CNR2 (0.42) | CNR2CNR1TP53SMN1; SMN2NPC1 | |
| SCHEMBL1464390 | 0.79 | CNR2 (0.71) | CNR2CNR1CYP3A4GAACYP2C19 | |
| SCHEMBL1465115 | 0.78 | SMN1; SMN2 (0.65) | CNR2CNR1TP53SMN1; SMN2NPC1 | |
| SCHEMBL3961157 | 0.77 | CNR2 (0.40) | CNR2CNR1NPC1RAB9AMAPK1 | |
| SCHEMBL1463634 | 0.76 | CNR2 (0.66) | CNR2CNR1 | |
| SCHEMBL3962989 | 0.76 | CNR2 (0.53) | CNR2CNR1LMNA | |
| SCHEMBL1465923 | 0.76 | CNR2 (0.68) | CNR2CNR1LMNACYP3A4GAA | |
| SCHEMBL3964882 | 0.75 | CNR2 (0.67) | CNR2CNR1LMNACYP3A4GAA | |
| SCHEMBL1465913 | 0.75 | CNR2 (0.67) | CNR2CNR1LMNACYP3A4GAA | |
| SCHEMBL4064491 | 0.74 | MEN1 (0.52) | CNR2CNR1TP53SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081905-A2 | SULFONYL COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR | Boehringer Ingelheim International GmbH (DE) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008014199-A2 | SULFONYL COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-01-31 | — | — | WO | disclosed |