Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | P2RY1 | P47900 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | CTSA | P10619 | 5/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.32 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | PTGFR | P43088 | 2/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2079067 | 0.90 | ABL1 (0.34) | ABL1P2RY1GAADHODHNR3C1 | |
| SCHEMBL13353942 | 0.89 | ABL1 (0.35) | ABL1P2RY1GAADHODHNR3C1 | |
| SCHEMBL4070987 | 0.86 | P2RY1 (0.33) | ABL1P2RY1NR3C1CTSAPTGFR | |
| SCHEMBL2080175 | 0.81 | DGAT2 (0.39) | MAPK13MAPK12MAPK11MAPK14NTRK1 | |
| SCHEMBL2826952 | 0.77 | MAPK14 (0.44) | ABL1GAADHODHMAPK13MAPK12 | |
| SCHEMBL2081557 | 0.75 | CCNT1 (0.34) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL13321786 | 0.69 | CCNT1 (0.34) | — | |
| SCHEMBL13321787 | 0.69 | CCNT1 (0.35) | — | |
| SCHEMBL13353994 | 0.68 | CNR2 (0.33) | — | |
| SCHEMBL2079338 | 0.67 | MAPK14 (0.43) | MAPK13MAPK12MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049537-A1 | 1, 7-NAPHTHYRIDINE DERIVATIVES AS P38 MAP KINASE INHIBITORS | Laboratorios Almirall, S.A. (ES) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008017461-A1 | 1, 7-NAPHTHYRIDINE DERIVATIVES AS P38 MAP KINASE INHIBITORS | LABORATORIOS ALMIRALL, S.A. (ES) | 2008-02-14 | — | — | WO | disclosed |