Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 8/20 | 0.40 |
| ▸ | CDK9 | P50750 | 3/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | ABL2 | P42684 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
| ▸ | CCNH | P51946 | 1/20 | 0.39 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2078245 | 0.90 | CYP17A1 (0.48) | KITCYP17A1CDK9CCNT1MAP4K4 | |
| SCHEMBL4078207 | 0.80 | MAPK14 (0.61) | MAPK14CYP17A1NR3C1 | |
| SCHEMBL2078751 | 0.79 | MAPK14 (0.65) | MAPK14CDK9CCNT1IDO1 | |
| SCHEMBL4074605 | 0.79 | MAPK14 (0.57) | MAPK14CYP17A1CDK9CCNT1MAP4K4 | |
| SCHEMBL2079054 | 0.78 | MAPK14 (0.51) | MAPK14CYP17A1CDK9CCNT1 | |
| SCHEMBL2078019 | 0.76 | MAPK14 (0.58) | MAPK14CYP17A1CDK9CCNT1MAP4K4 | |
| SCHEMBL4067939 | 0.73 | MAPK14 (0.60) | MAPK14IDO1 | |
| SCHEMBL2079875 | 0.69 | MAPK14 (0.66) | MAPK14IDO1 | |
| SCHEMBL2079261 | 0.69 | MAPK14 (0.65) | MAPK14CYP17A1 | |
| SCHEMBL2080876 | 0.68 | CYP17A1 (0.44) | MAPK14CYP17A1CDK9CDK1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049537-A1 | 1, 7-NAPHTHYRIDINE DERIVATIVES AS P38 MAP KINASE INHIBITORS | Laboratorios Almirall, S.A. (ES) | 2009-04-22 | — | — | EP | claimed |
| WO-2008017461-A1 | 1, 7-NAPHTHYRIDINE DERIVATIVES AS P38 MAP KINASE INHIBITORS | LABORATORIOS ALMIRALL, S.A. (ES) | 2008-02-14 | — | — | WO | claimed |