Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.60 |
| ▸ | UGCG | Q16739 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2079875 | 0.94 | MAPK14 (0.66) | MAPK14UGCGIDO1TDO2ALOX5AP | |
| SCHEMBL2080033 | 0.92 | MAPK14 (0.68) | MAPK14ALOX5APFEN1 | |
| SCHEMBL2079342 | 0.83 | MAPK14 (0.66) | MAPK14UGCG | |
| SCHEMBL2079261 | 0.80 | MAPK14 (0.65) | MAPK14 | |
| SCHEMBL2080402 | 0.78 | MAPK14 (0.51) | MAPK14 | |
| SCHEMBL4067333 | 0.78 | MAPK14 (0.59) | MAPK14UGCGIDO1TDO2MAP4K1 | |
| SCHEMBL2078613 | 0.78 | MAPK14 (0.53) | MAPK14 | |
| SCHEMBL4246296 | 0.77 | MAPK14 (0.44) | MAPK14MAP4K1 | |
| SCHEMBL2080178 | 0.77 | MAPK14 (0.53) | MAPK14 | |
| SCHEMBL2079054 | 0.77 | MAPK14 (0.51) | MAPK14UGCG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049537-A1 | 1, 7-NAPHTHYRIDINE DERIVATIVES AS P38 MAP KINASE INHIBITORS | Laboratorios Almirall, S.A. (ES) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008017461-A1 | 1, 7-NAPHTHYRIDINE DERIVATIVES AS P38 MAP KINASE INHIBITORS | LABORATORIOS ALMIRALL, S.A. (ES) | 2008-02-14 | — | — | WO | disclosed |