Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 10/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.53 |
| ▸ | TSHR | P16473 | 7/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8128074 | 0.93 | CYP2D6 (0.60) | CYP2D6CYP3A4TSHRALDH1A1CYP1A2 | |
| SCHEMBL4072585 | 0.91 | CYP2D6 (0.53) | CYP2D6CYP3A4TSHRALDH1A1CYP1A2 | |
| SCHEMBL4070218 | 0.90 | CYP2D6 (0.53) | CYP2D6CYP3A4TSHRALDH1A1CYP1A2 | |
| SCHEMBL4077814 | 0.89 | CYP2D6 (0.53) | CYP2D6CYP3A4TSHRALDH1A1CYP1A2 | |
| SCHEMBL4069184 | 0.89 | CYP2D6 (0.61) | CYP2D6CYP3A4TSHRALDH1A1CYP1A2 | |
| SCHEMBL1241618 | 0.86 | TP53 (0.55) | CYP2D6CYP3A4TSHRALDH1A1CYP1A2 | |
| SCHEMBL4073865 | 0.80 | CYP2D6 (0.53) | CYP2D6CYP3A4TSHRALDH1A1CYP1A2 | |
| SCHEMBL8141053 | 0.75 | TP53 (0.51) | CYP2D6CYP3A4TSHRALDH1A1CYP1A2 | |
| SCHEMBL21419845 | 0.74 | CYP2D6 (0.60) | CYP2D6CYP3A4TSHRALDH1A1CYP1A2 | |
| SCHEMBL13744225 | 0.74 | CYP2D6 (0.60) | CYP2D6CYP3A4TSHRALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2037919-A2 | METHOD OF USING SUBSTITUTED PIPERIDINES THAT INCREASE P53 ACTIVITY | SCHERING CORPORATION (US) | 2009-03-25 | — | — | EP | disclosed |
| WO-2008005266-A2 | METHOD OF USING SUBSTITUTED PIPERIDINES THAT INCREASE P53 ACTIVITY | SCHERING CORPORATION (US) | 2008-01-10 | — | — | WO | disclosed |
| US-20080004286-A1 | Method of Using Substituted Piperidines that Increase P53 Activity | SCHERING CORPORATION | 2008-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004286-A1 | Method of Using Substituted Piperidines that Increase P53 Activity | TP53, MDM2, TP53BP1 | CYP2D6 3444/4885CYP3A4 3524/4885TSHR 4156/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.