Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 11/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.52 |
| ▸ | TSHR | P16473 | 7/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8128074 | 0.92 | CYP2D6 (0.60) | CYP2D6ALDH1A1CYP3A4TSHRKDM4E | |
| SCHEMBL4069184 | 0.91 | CYP2D6 (0.61) | CYP2D6ALDH1A1CYP3A4TSHRKMT2A | |
| SCHEMBL4072585 | 0.89 | CYP2D6 (0.53) | CYP2D6ALDH1A1CYP3A4TSHRHRH3 | |
| SCHEMBL4072580 | 0.89 | CYP2D6 (0.53) | CYP2D6ALDH1A1CYP3A4TSHRKMT2A | |
| SCHEMBL1241618 | 0.85 | TP53 (0.55) | CYP2D6ALDH1A1CYP3A4TSHRGAA | |
| SCHEMBL4073865 | 0.84 | CYP2D6 (0.53) | CYP2D6ALDH1A1CYP3A4TSHRKMT2A | |
| SCHEMBL4070218 | 0.82 | CYP2D6 (0.53) | CYP2D6ALDH1A1CYP3A4TSHRKMT2A | |
| SCHEMBL8141053 | 0.76 | TP53 (0.51) | CYP2D6ALDH1A1CYP3A4TSHRKDM4E | |
| SCHEMBL14447010 | 0.75 | MAP4K4 (0.42) | ALDH1A1TSHRKMT2ALMNAMEN1 | |
| SCHEMBL9174059 | 0.75 | CYP2D6 (0.55) | CYP2D6ALDH1A1CYP3A4TSHRCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2037919-A2 | METHOD OF USING SUBSTITUTED PIPERIDINES THAT INCREASE P53 ACTIVITY | SCHERING CORPORATION (US) | 2009-03-25 | — | — | EP | disclosed |
| WO-2008005266-A2 | METHOD OF USING SUBSTITUTED PIPERIDINES THAT INCREASE P53 ACTIVITY | SCHERING CORPORATION (US) | 2008-01-10 | — | — | WO | disclosed |
| US-20080004286-A1 | Method of Using Substituted Piperidines that Increase P53 Activity | SCHERING CORPORATION | 2008-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004286-A1 | Method of Using Substituted Piperidines that Increase P53 Activity | TP53, MDM2, TP53BP1 | CYP2D6 3444/4885ALDH1A1 1925/4885CYP3A4 3524/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.