Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 3/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
| ▸ | CA2 | P00918 | 3/20 | 0.47 |
| ▸ | CA9 | Q16790 | 3/20 | 0.47 |
| ▸ | CTSS | P25774 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4073139 | 0.98 | EPHX1 (0.60) | EPHX1TDP1KMT2AGAAMEN1 | |
| SCHEMBL4077144 | 0.93 | TDP1 (0.59) | EPHX1TDP1KMT2AGAAMEN1 | |
| SCHEMBL6799750 | 0.88 | EPHX1 (0.63) | EPHX1TDP1KMT2AGAAMEN1 | |
| SCHEMBL15358145 | 0.86 | TDP1 (0.46) | EPHX1TDP1KMT2AGAAMEN1 | |
| SCHEMBL4068905 | 0.86 | TDP1 (0.51) | EPHX1TDP1KMT2AGAAMEN1 | |
| SCHEMBL4071347 | 0.86 | TDP1 (0.51) | EPHX1TDP1KMT2AGAAMEN1 | |
| SCHEMBL16023429 | 0.86 | TDP1 (0.51) | EPHX1TDP1KMT2AGAAMEN1 | |
| SCHEMBL8393248 | 0.84 | EPHX1 (0.48) | EPHX1KMT2AMEN1SIGMAR1HRH4 | |
| SCHEMBL18256901 | 0.84 | EPHX1 (0.51) | EPHX1TDP1KMT2AGAAMEN1 | |
| SCHEMBL12634634 | 0.83 | EPHX1 (0.51) | EPHX1TDP1KMT2AGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038041-A2 | THERAPEUTIC COMPOUNDS AND THEIR USE IN CANCER | Myriad Genetics, Inc. (US) | 2009-03-25 | — | — | EP | disclosed |
| WO-2007134298-A2 | THERAPEUTIC COMPOUNDS AND THEIR USE IN CANCER | MYRIAD GENETICS, INC. (US) | 2007-11-22 | — | — | WO | disclosed |