Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 6/20 | 0.49 |
| ▸ | CA1 | P00915 | 6/20 | 0.49 |
| ▸ | CA2 | P00918 | 6/20 | 0.49 |
| ▸ | CA9 | Q16790 | 6/20 | 0.49 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | FPR3 | P25089 | 2/20 | 0.41 |
| ▸ | FPR2 | P25090 | 2/20 | 0.41 |
| ▸ | STK17B | O94768 | 1/20 | 0.41 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4072834 | 0.93 | EPHX1 (0.57) | TDP1KMT2AMEN1GAAEPHX1 | |
| SCHEMBL4073139 | 0.92 | EPHX1 (0.60) | TDP1KMT2AMEN1GAAEPHX1 | |
| SCHEMBL18256901 | 0.90 | EPHX1 (0.51) | TDP1KMT2AMEN1GAAEPHX1 | |
| SCHEMBL12648114 | 0.89 | EPHX1 (0.55) | TDP1KMT2AMEN1GAAEPHX1 | |
| SCHEMBL16023429 | 0.89 | TDP1 (0.51) | TDP1KMT2AMEN1GAAEPHX1 | |
| SCHEMBL6243164 | 0.89 | TDP1 (0.59) | TDP1KMT2AMEN1GAAEPHX1 | |
| SCHEMBL4068905 | 0.89 | TDP1 (0.51) | TDP1KMT2AMEN1GAAEPHX1 | |
| SCHEMBL4071347 | 0.89 | TDP1 (0.51) | TDP1KMT2AMEN1GAAEPHX1 | |
| SCHEMBL7816256 | 0.87 | TDP1 (0.61) | TDP1KMT2AMEN1GAAEPHX1 | |
| SCHEMBL19594077 | 0.86 | TDP1 (0.56) | TDP1KMT2AMEN1GAAEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038041-A2 | THERAPEUTIC COMPOUNDS AND THEIR USE IN CANCER | Myriad Genetics, Inc. (US) | 2009-03-25 | — | — | EP | disclosed |
| WO-2007134298-A2 | THERAPEUTIC COMPOUNDS AND THEIR USE IN CANCER | MYRIAD GENETICS, INC. (US) | 2007-11-22 | — | — | WO | disclosed |