Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIP4K2A | P48426 | 7/20 | 0.40 |
| ▸ | PIP4K2C | Q8TBX8 | 7/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 7/20 | 0.36 |
| ▸ | EGFR | P00533 | 5/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | PRKCI | P41743 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4068191 | 0.89 | FLT1 (0.38) | PIP4K2APIP4K2CNPC1RAB9AFLT1 | |
| SCHEMBL4075468 | 0.89 | NPC1 (0.39) | PIP4K2APIP4K2CNPC1RAB9AFLT1 | |
| SCHEMBL3939316 | 0.88 | NPC1 (0.39) | PIP4K2APIP4K2CNPC1RAB9AFLT1 | |
| SCHEMBL4077908 | 0.88 | STK17B (0.40) | PIP4K2APIP4K2CNPC1RAB9AFLT1 | |
| SCHEMBL4072990 | 0.87 | NPC1 (0.39) | PIP4K2APIP4K2CNPC1RAB9AFLT1 | |
| SCHEMBL4071195 | 0.86 | FLT1 (0.46) | NPC1RAB9AFLT1EGFRKDR | |
| SCHEMBL4070509 | 0.86 | NPC1 (0.37) | PIP4K2APIP4K2CNPC1RAB9AFLT1 | |
| SCHEMBL4065656 | 0.85 | FLT1 (0.45) | NPC1RAB9AFLT1EGFRKDR | |
| SCHEMBL3936999 | 0.85 | NPC1 (0.42) | PIP4K2APIP4K2CNPC1RAB9AFLT1 | |
| SCHEMBL4251366 | 0.85 | KMT2A (0.39) | PIP4K2APIP4K2CNPC1RAB9AFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2014662-A1 | Indolyl alkyl thieno-pyrimidyl amines as modulators of EP2 receptors | Bayer Schering Pharma Aktiengesellschaft (DE) | 2009-01-14 | — | — | EP | disclosed |