Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OTUD7B | Q6GQQ9 | 1/20 | 0.44 |
| ▸ | CCNC | P24863 | 14/20 | 0.36 |
| ▸ | CDK8 | P49336 | 14/20 | 0.36 |
| ▸ | JAK1 | P23458 | 3/20 | 0.34 |
| ▸ | TYK2 | P29597 | 3/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4072997 | 0.77 | OTUD7B (0.47) | OTUD7BCCNCCDK8JAK1TYK2 | |
| SCHEMBL11889737 | 0.77 | CRBN (0.47) | IDO1 | |
| SCHEMBL18711886 | 0.72 | OTUD7B (0.46) | OTUD7BCCNCCDK8JAK1TYK2 | |
| SCHEMBL29890275 | 0.72 | OTUD7B (0.46) | OTUD7BCCNCCDK8JAK1TYK2 | |
| SCHEMBL4073250 | 0.71 | GRIN1 (0.33) | — | |
| SCHEMBL18113471 | 0.71 | OTUD7B (0.53) | OTUD7BCCNCCDK8JAK1TYK2 | |
| SCHEMBL20395783 | 0.71 | OTUD7B (0.53) | OTUD7BCCNCCDK8JAK1TYK2 | |
| SCHEMBL20395821 | 0.71 | OTUD7B (0.53) | OTUD7BCCNCCDK8JAK1TYK2 | |
| SCHEMBL479513 | 0.71 | — | — | |
| SCHEMBL5559483 | 0.71 | OTUD7B (0.51) | OTUD7BCCNCCDK8JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2032535-B1 | SPIROCYCLIC NITRILES AS PROTEASE INHIBITORS | SANOFI SA (FR) | 2012-08-01 | — | — | EP | claimed |
| EP-2032535-A1 | SPIROCYCLIC NITRILES AS PROTEASE INHIBITORS | Sanofi-Aventis (FR) | 2009-03-11 | — | — | EP | claimed |
| WO-2007137738-A1 | SPIROCYCLIC NITRILES AS PROTEASE INHIBITORS | SANOFI-AVENTIS (DE) | 2007-12-06 | — | — | WO | claimed |
| EP-2520568-A1 | Spirocyclic nitriles as inhibitors of protease | SANOFI (FR) | 2012-11-07 | — | — | EP | disclosed |
| EP-2032535-B1 | SPIROCYCLIC NITRILES AS PROTEASE INHIBITORS | SANOFI SA (FR) | 2012-08-01 | — | — | EP | disclosed |
| EP-2032535-A1 | SPIROCYCLIC NITRILES AS PROTEASE INHIBITORS | Sanofi-Aventis (FR) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007137738-A1 | SPIROCYCLIC NITRILES AS PROTEASE INHIBITORS | SANOFI-AVENTIS (DE) | 2007-12-06 | — | — | WO | disclosed |