Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA5 | O75582 | 9/20 | 0.66 |
| ▸ | AKT1 | P31749 | 5/20 | 0.66 |
| ▸ | RPS6KA1 | Q15418 | 3/20 | 0.66 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4064408 | 0.91 | RPS6KA5 (0.66) | RPS6KA5AKT1RPS6KA1ROCK1SLC2A1 | |
| SCHEMBL4243398 | 0.89 | RPS6KA5 (0.53) | RPS6KA5AKT1RPS6KA1ROCK1MAPT | |
| SCHEMBL5066065 | 0.89 | AKT1 (0.53) | RPS6KA5AKT1RPS6KA1ROCK1MAPT | |
| SCHEMBL4062863 | 0.89 | AKT1 (0.54) | RPS6KA5AKT1RPS6KA1ROCK1MAPT | |
| SCHEMBL4062121 | 0.84 | RPS6KA5 (0.69) | RPS6KA5AKT1RPS6KA1ROCK1PRKACA | |
| SCHEMBL4061112 | 0.83 | RPS6KA5 (0.57) | RPS6KA5AKT1RPS6KA1ROCK1SLC2A1 | |
| SCHEMBL4566808 | 0.82 | RPS6KA5 (0.67) | RPS6KA5AKT1RPS6KA1ROCK1PRKACA | |
| SCHEMBL4060743 | 0.82 | AKT1 (0.55) | RPS6KA5AKT1RPS6KA1ROCK1SLC2A1 | |
| SCHEMBL4069078 | 0.82 | RPS6KA5 (0.46) | RPS6KA5AKT1RPS6KA1MAPTALDH1A1 | |
| SCHEMBL4063210 | 0.82 | AKT1 (0.57) | RPS6KA5AKT1RPS6KA1ROCK1SLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1653961-A4 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORP (US) | 2009-04-01 | — | — | EP | disclosed |
| US-20080255143-A1 | Inhibitors of Akt Activity | SMITHKLINE BEECHAM CORPORATION (PA) | 2008-10-16 | — | — | US | disclosed |
| EP-1653961-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005011700-A1 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2005-02-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255143-A1 | Inhibitors of Akt Activity | PI4KB, PIK3CA, AKT2 | RPS6KA5 156/4885AKT1 5/4885RPS6KA1 127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.