Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA5 | O75582 | 13/20 | 0.67 |
| ▸ | AKT1 | P31749 | 6/20 | 0.67 |
| ▸ | RPS6KA1 | Q15418 | 4/20 | 0.67 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.52 |
| ▸ | PRKACA | P17612 | 1/20 | 0.49 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5062967 | 0.90 | RPS6KA5 (0.67) | RPS6KA5AKT1RPS6KA1ROCK1PRKACA | |
| Hydrochloric Acid SCHEMBL5062655 | 0.88 | RPS6KA5 (0.54) | RPS6KA5AKT1RPS6KA1ROCK1PRKACA | |
| SCHEMBL4062121 | 0.88 | RPS6KA5 (0.69) | RPS6KA5AKT1RPS6KA1ROCK1PRKACA | |
| SCHEMBL4064408 | 0.85 | RPS6KA5 (0.66) | RPS6KA5AKT1RPS6KA1ROCK1PRKACA | |
| SCHEMBL4065881 | 0.84 | RPS6KA5 (0.60) | RPS6KA5AKT1RPS6KA1ROCK1PRKACA | |
| SCHEMBL4066879 | 0.84 | AKT1 (0.84) | RPS6KA5AKT1RPS6KA1ROCK1 | |
| SCHEMBL5058506 | 0.83 | RPS6KA5 (0.65) | RPS6KA5AKT1RPS6KA1ROCK1PRKACA | |
| SCHEMBL4073188 | 0.82 | RPS6KA5 (0.66) | RPS6KA5AKT1RPS6KA1ROCK1PRKACA | |
| SCHEMBL4062167 | 0.82 | RPS6KA5 (0.60) | RPS6KA5AKT1RPS6KA1ROCK1PRKACA | |
| SCHEMBL5063634 | 0.81 | AKT1 (0.91) | RPS6KA5AKT1RPS6KA1ROCK1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1653961-A4 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORP (US) | 2009-04-01 | — | — | EP | disclosed |
| EP-1653961-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005011700-A1 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2005-02-10 | — | — | WO | disclosed |