Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | SLC18A3 | Q16572 | 3/20 | 0.38 |
| ▸ | CCR5 | P51681 | 5/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.34 |
| ▸ | HTR7 | P34969 | 2/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.33 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8891712 | 0.79 | KCNH2 (0.46) | KCNH2HRH3SLC18A3DRD2CA12 | |
| SCHEMBL27764392 | 0.74 | CSNK1D (0.52) | CSNK1DCSNK1G2KCNH2HRH3SLC18A3 | |
| SCHEMBL4881149 | 0.71 | CSNK1D (0.55) | CSNK1DCSNK1G2KCNH2HRH3SLC18A3 | |
| SCHEMBL4070366 | 0.70 | SLC18A3 (0.49) | SLC18A3 | |
| SCHEMBL27498942 | 0.68 | KCNH2 (0.52) | KCNH2HRH3SLC18A3CCR5DRD2 | |
| SCHEMBL4071190 | 0.68 | NAMPT (0.48) | CSNK1DCSNK1G2CCR5 | |
| SCHEMBL4076805 | 0.66 | SLC18A3 (0.46) | SLC18A3CCR5DRD2CARM1PRMT6 | |
| SCHEMBL24291907 | 0.65 | KCNH2 (0.53) | KCNH2HRH3SLC18A3CCR5DRD2 | |
| SCHEMBL3710421 | 0.63 | SLC18A3 (0.52) | SLC18A3DRD2CARM1PRMT6 | |
| SCHEMBL16255639 | 0.63 | KCNH2 (0.54) | KCNH2HRH3SLC18A3DRD2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099454-A2 | AMINOPYRROLIDINES AS CHEMOKINE RECEPTOR ANTAGONISTS | Abbott Laboratories (US) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008060621-A2 | AMINOPYRROLIDINES AS CHEMOKINE RECEPTOR ANTAGONISTS | ABBOTT LABORATORIES (US) | 2008-05-22 | — | — | WO | disclosed |