Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 6/20 | 0.47 |
| ▸ | JAK2 | O60674 | 4/20 | 0.45 |
| ▸ | JAK3 | P52333 | 4/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.45 |
| ▸ | AURKA | O14965 | 3/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.45 |
| ▸ | PAK4 | O96013 | 2/20 | 0.45 |
| ▸ | ABL1 | P00519 | 2/20 | 0.45 |
| ▸ | CSF1R | P07333 | 2/20 | 0.45 |
| ▸ | RET | P07949 | 2/20 | 0.45 |
| ▸ | LTK | P29376 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.45 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.45 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.45 |
| ▸ | MST1R | Q04912 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3969173 | 0.92 | TTK (0.40) | TTKJAK2JAK3LRRK2PTK2 | |
| SCHEMBL4075270 | 0.91 | TTK (0.48) | TTKJAK2JAK3LRRK2PTK2 | |
| SCHEMBL3967492 | 0.91 | MAPK1 (0.41) | TTKJAK2JAK3LRRK2PTK2 | |
| SCHEMBL3970201 | 0.91 | MAPK1 (0.41) | TTKJAK2JAK3LRRK2PTK2 | |
| SCHEMBL3974734 | 0.91 | KDR (0.46) | TTKJAK2JAK3LRRK2PTK2 | |
| SCHEMBL3964255 | 0.90 | LRRK2 (0.49) | TTKJAK2JAK3LRRK2PTK2 | |
| SCHEMBL3970782 | 0.90 | PLK4 (0.41) | TTKJAK2JAK3LRRK2PTK2 | |
| SCHEMBL3971535 | 0.89 | TTK (0.45) | TTKJAK2JAK3LRRK2PTK2 | |
| SCHEMBL4078306 | 0.87 | TTK (0.62) | TTKJAK2JAK3LRRK2PTK2 | |
| SCHEMBL13883520 | 0.87 | LRRK2 (0.41) | TTKJAK3LRRK2CHEK1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |