Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TTK | P33981 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 4/20 | 0.39 |
| ▸ | CDK1 | P06493 | 2/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 5/20 | 0.37 |
| ▸ | MERTK | Q12866 | 3/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | JAK3 | P52333 | 2/20 | 0.37 |
| ▸ | MET | P08581 | 2/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | ACP1 | P24666 | 2/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | PAK4 | O96013 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3967492 | 1.00 | MAPK1 (0.41) | MAPK1L3MBTL1TTKKDRCDK1 | |
| SCHEMBL3969173 | 0.99 | TTK (0.40) | MAPK1L3MBTL1TTKKDRCDK1 | |
| SCHEMBL3970782 | 0.92 | PLK4 (0.41) | TTKKDRJAK1AXLMERTK | |
| SCHEMBL4073485 | 0.91 | TTK (0.47) | TTKKDRAXLJAK2JAK3 | |
| SCHEMBL3975392 | 0.89 | PDPK1 (0.43) | KDRCDK1JAK1JAK2JAK3 | |
| SCHEMBL13883520 | 0.89 | LRRK2 (0.41) | TTKKDRJAK1AXLMERTK | |
| SCHEMBL3975880 | 0.86 | LRRK2 (0.39) | TTKKDRJAK1AXLMERTK | |
| SCHEMBL3975882 | 0.86 | AXL (0.35) | TTKKDRJAK1AXLMERTK | |
| SCHEMBL13883571 | 0.84 | SRC (0.46) | KDRJAK1AXLJAK2JAK3 | |
| SCHEMBL13883586 | 0.83 | CYP11B1 (0.42) | TTKJAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |