Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.48 |
| ▸ | CSF1R | P07333 | 5/20 | 0.48 |
| ▸ | FLT1 | P17948 | 5/20 | 0.48 |
| ▸ | FLT3 | P36888 | 5/20 | 0.48 |
| ▸ | KIT | P10721 | 4/20 | 0.48 |
| ▸ | FLT4 | P35916 | 4/20 | 0.48 |
| ▸ | LCK | P06239 | 4/20 | 0.48 |
| ▸ | FYN | P06241 | 4/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.48 |
| ▸ | NTRK2 | Q16620 | 4/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.48 |
| ▸ | LYN | P07948 | 3/20 | 0.48 |
| ▸ | SRC | P12931 | 3/20 | 0.48 |
| ▸ | BLK | P51451 | 3/20 | 0.48 |
| ▸ | JAK2 | O60674 | 3/20 | 0.48 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.48 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.48 |
| ▸ | TAOK1 | Q7L7X3 | 3/20 | 0.48 |
| ▸ | HIPK2 | Q9H2X6 | 3/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2817549 | 0.92 | FLT3 (0.48) | KDRCSF1RFLT1FLT3KIT | |
| SCHEMBL12973426 | 0.88 | KDR (0.51) | KDRCSF1RFLT1FLT3KIT | |
| SCHEMBL2816690 | 0.88 | CSF1R (0.48) | KDRCSF1RFLT1FLT3KIT | |
| SCHEMBL2821063 | 0.86 | KDR (0.63) | KDRCSF1RFLT1FLT3KIT | |
| SCHEMBL2817544 | 0.86 | CSF1R (0.47) | KDRCSF1RFLT1FLT3KIT | |
| SCHEMBL12973411 | 0.85 | IDH2 (0.49) | KDRCSF1RFLT1FLT3KIT | |
| SCHEMBL12973413 | 0.84 | LMNA (0.46) | KDRCSF1RFLT1FLT3KIT | |
| SCHEMBL12973419 | 0.82 | MEN1 (0.53) | KDRCSF1RFLT1FLT3KIT | |
| SCHEMBL12973414 | 0.82 | KDR (0.45) | KDRFLT3KITAURKAALK | |
| SCHEMBL4078557 | 0.81 | KDR (0.55) | KDRCSF1RFLT1FLT3KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061790-A1 | SUBSTITUTED AMINOPYRAZOLOPYRIDINES AND SALTS THEREOF, THEIR PREPARATIONS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Bayer Schering Pharma Aktiengesellschaft (DE) | 2009-05-27 | — | — | EP | claimed |
| WO-2007144204-A1 | SUBSTITUTED AMINOPYRAZOLOPYRIDINES AND SALTS THEREOF, THEIR PREPARATIONS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2007-12-21 | — | — | WO | claimed |