Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 12/20 | 0.60 |
| ▸ | IGF1R | P08069 | 8/20 | 0.46 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4067395 | 1.00 | NTRK1 (0.60) | NTRK1IGF1RMAP4K1RPS6KB1 | |
| SCHEMBL27674599 | 1.00 | NTRK1 (0.60) | NTRK1IGF1RMAP4K1RPS6KB1 | |
| SCHEMBL3341202 | 0.91 | NTRK1 (0.73) | NTRK1IGF1R | |
| SCHEMBL29794640 | 0.91 | NTRK1 (0.73) | NTRK1IGF1R | |
| SCHEMBL4076088 | 0.91 | NTRK1 (0.73) | NTRK1IGF1R | |
| SCHEMBL27674715 | 0.91 | NTRK1 (0.73) | NTRK1IGF1R | |
| SCHEMBL29794659 | 0.90 | NTRK1 (0.71) | NTRK1IGF1R | |
| SCHEMBL4240838 | 0.90 | NTRK1 (0.71) | NTRK1IGF1R | |
| SCHEMBL4071495 | 0.90 | NTRK1 (0.56) | NTRK1IGF1R | |
| SCHEMBL4074207 | 0.90 | NTRK1 (0.71) | NTRK1IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686999-B1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSINE KINASES | ASTRAZENECA AB (SE) | 2009-07-01 | — | — | EP | disclosed |
| CN-1905884-A | Pyrazole derivatives as inhibitors of receptor tyrosyne kinases | ASTRAZENECA AB (SE) | 2007-01-31 | — | — | CN | disclosed |