Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4072758 | 0.88 | — | — | |
| SCHEMBL4065777 | 0.88 | TNK2 (0.34) | TNK2 | |
| SCHEMBL4067736 | 0.87 | IGF1R (0.30) | IGF1R | |
| SCHEMBL398785 | 0.86 | IGF1R (0.39) | IGF1RCYP3A4 | |
| SCHEMBL4065196 | 0.86 | IGF1R (0.37) | IGF1RCYP3A4TNK2 | |
| SCHEMBL4074268 | 0.84 | — | — | |
| SCHEMBL400618 | 0.83 | IGF1R (0.47) | IGF1RCYP3A4TNK2 | |
| SCHEMBL398029 | 0.80 | IGF1R (0.41) | IGF1R | |
| SCHEMBL401747 | 0.77 | IGF1R (0.38) | IGF1RCYP3A4TNK2 | |
| SCHEMBL398353 | 0.77 | IGF1R (0.35) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740591-B1 | 6,6-BICYCLIC RING SUBSTITUTED HETEROBICYCLIC PROTEIN KINASE INHIBITORS | OSI PHARM INC (US) | 2009-06-17 | — | — | EP | claimed |