Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 3/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | INSR | P06213 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4066036 | 0.90 | EGFR (0.32) | IGF1REGFRINSRCYP3A4KDR | |
| SCHEMBL4072094 | 0.88 | — | — | |
| SCHEMBL4071108 | 0.88 | TNK2 (0.34) | TNK2 | |
| SCHEMBL402424 | 0.86 | IGF1R (0.41) | IGF1REGFRINSRCYP3A4KDR | |
| SCHEMBL4074254 | 0.86 | IGF1R (0.36) | IGF1RCYP3A4TNK2 | |
| SCHEMBL4067736 | 0.85 | IGF1R (0.30) | IGF1R | |
| SCHEMBL397604 | 0.83 | IGF1R (0.49) | IGF1REGFRINSRCYP3A4KDR | |
| SCHEMBL402211 | 0.82 | IGF1R (0.47) | IGF1REGFRINSRCYP3A4KDR | |
| SCHEMBL4074268 | 0.81 | — | — | |
| SCHEMBL398029 | 0.79 | IGF1R (0.41) | IGF1RINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740591-B1 | 6,6-BICYCLIC RING SUBSTITUTED HETEROBICYCLIC PROTEIN KINASE INHIBITORS | OSI PHARM INC (US) | 2009-06-17 | — | — | EP | claimed |