Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SLC5A2 | P31639 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.39 |
| ▸ | MTHFD2 | P13995 | 1/20 | 0.39 |
| ▸ | PREP | P48147 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL214943 | 0.88 | SCD (0.51) | MEN1KMT2ASLC5A2GPR139POLB | |
| SCHEMBL216192 | 0.86 | PTGDR2 (0.46) | SMN1; SMN2SLC5A2TP53PTGDR2ALDH1A1 | |
| SCHEMBL216751 | 0.85 | SLC5A2 (0.40) | SMN1; SMN2SLC5A2TP53PTGDR2ALDH1A1 | |
| SCHEMBL216937 | 0.83 | SMN1; SMN2 (0.47) | SMN1; SMN2MAPK1KMT2ATP53PTGDR2 | |
| SCHEMBL406980 | 0.80 | SLC5A2 (0.43) | SMN1; SMN2MAPK1KMT2ASLC5A2LMNA | |
| SCHEMBL216748 | 0.80 | EGLN1 (0.44) | SLC5A2TSHRSLC5A1MTHFD2GAA | |
| SCHEMBL2735997 | 0.79 | IKBKB (0.48) | SMN1; SMN2TP53PTGDR2LMNAGPR139 | |
| SCHEMBL216803 | 0.77 | SCD (0.55) | SLC5A2PTGDR2LMNAHTTMAPT | |
| SCHEMBL215875 | 0.77 | SMN1; SMN2 (0.45) | SMN1; SMN2MEN1MAPK1KMT2ASLC5A2 | |
| SCHEMBL215242 | 0.76 | POLB (0.51) | MEN1KMT2ASLC5A2PTGDR2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065227-A1 | TRIAZOLOPYRIDINONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065227-A1 | TRIAZOLOPYRIDINONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS | SCD, SCD5, FASN | SMN1; SMN2 3270/4885MEN1 4716/4885MAPK1 1952/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.