Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.62 |
| ▸ | BRAF | P15056 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 5/20 | 0.56 |
| ▸ | JAK3 | P52333 | 5/20 | 0.56 |
| ▸ | JAK1 | P23458 | 2/20 | 0.56 |
| ▸ | TYK2 | P29597 | 2/20 | 0.56 |
| ▸ | BRD4 | O60885 | 1/20 | 0.56 |
| ▸ | RET | P07949 | 1/20 | 0.56 |
| ▸ | FLT3 | P36888 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | AXL | P30530 | 5/20 | 0.54 |
| ▸ | BACE1 | P56817 | 2/20 | 0.54 |
| ▸ | SRC | P12931 | 6/20 | 0.54 |
| ▸ | KDR | P35968 | 3/20 | 0.53 |
| ▸ | YES1 | P07947 | 2/20 | 0.53 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.53 |
| ▸ | EGFR | P00533 | 2/20 | 0.52 |
| ▸ | TEK | Q02763 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12278133 | 0.86 | HRH3 (0.69) | HRH3BRAFJAK2JAK3JAK1 | |
| SCHEMBL4254804 | 0.84 | AXL (0.64) | HRH3BRAFJAK2JAK3AXL | |
| SCHEMBL270635 | 0.84 | MEN1 (0.67) | HRH3BRAFJAK2JAK3JAK1 | |
| SCHEMBL12109533 | 0.82 | HRH3 (0.77) | HRH3BRAFJAK2JAK3AXL | |
| SCHEMBL31745353 | 0.81 | JAK1 (0.59) | HRH3BRAFJAK2JAK3JAK1 | |
| SCHEMBL12278016 | 0.81 | HRH3 (0.63) | HRH3BRAFJAK2JAK3JAK1 | |
| SCHEMBL3973092 | 0.81 | SRC (0.65) | HRH3BRAFJAK2JAK3JAK1 | |
| SCHEMBL3963144 | 0.80 | AXL (0.68) | HRH3BRAFJAK2JAK3JAK1 | |
| SCHEMBL270422 | 0.80 | JAK1 (0.63) | HRH3BRAFJAK2JAK3JAK1 | |
| SCHEMBL3968637 | 0.80 | JAK1 (0.69) | HRH3BRAFJAK2JAK3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | claimed |